Cure for multiple sclerosis patients with hematopoietic stem cells

Multiple sclerosis, known as MS, is a disease that can affect all nerves. It can cause problems with organs like eye, ear, muscles, and other basic body functions. The effects of the disease can be different for everyone. Which means that some have more severe symptoms than others.

MS is diagnosed when your immune system attacks the myelin (fatty material) of the nerve fiber. The fatty material is very important in signal transmission. Damage in signal transmission means your brain can’t send signals through your body correctly.
Stem cell transplant in Multiple sclerosis

Cure for Multiple sclerosis

Researcher are looking for a cure for manny years now and a redical treatment seems to contain the answer.

The treatment seems very straightforward, wipes out the immune system and then regenerate again. This seems to halt progression of aggressive MS and even reverse its symptoms.

Scientists all around the globe are very exiting and data from clinical trials are showing interesting results.

But the radical treatment is at the same time very risky, and only likely to benefit a certain proportion of patients still in early stages of the disease.

The treatment is known as immunoablation and autologous hematopoietic stem cell transplantation. Doctors take stem cells from the patient bone marrow (hematopoietic stem cell are also found in large numbers in the umbilical cord) and bank them before giving a chemotherapy drugs that destroys the whole immune system.

The stem cells are then transplanted back into the body to generate a new disease free immune system without the problem of attacking nerve fibers.

13 years of data from clinical trial show zero patient relapsing and 70% experiencing a complete stop in disease progression.

In 40 percent of cases, patients saw lasting reversal of symptoms such as vision loss, muscle weakness and balance problems.

Some patients were able to return to school or work, get married and have children.

Risks of immunoablation and autologous hematopoietic stem cell transplantation.

The fact that patients have no immune system for a while makes them vulnerable for infectious. They also experience risks from the severe side effects of the chemo drugs used.

Survivor

“Thanks to this research I have been given a second chance at life.”,Jennifer Molson

Most promising medicine for relapsing multiple sclerosis

Immunoablation and autologous hematopoietic stem cell transplantation

Potential medicine for relapsing multiple sclerosis

Phase 3
Ocrelizumab
Cladribine
RPC1063
Laquinimod
Ponesimod
Ofatumumab

Phase 2
Anti-LINGO-1
ATX-MS-1467
Minocycline
Raltegravir
Amiselimod
Lipoic acid
Clemastine
ATL1102
Vatelizumab
Rituximab – development terminated

Potential treatments for primary progressive multiple sclerosis

Phase 3
Ocrelizumab
MD1003
Masitinib
Fingolimod

Phase 2
Fluoxetine
Ibudilast
Laquinimod
Natalizumab
Rituximab – development terminated

Potential treatments for secondary progressive multiple sclerosis

Phase 3
Siponimod
MD100
Masitinib

Phase 2
MS-SMART
Simvastatin
Riluzole
Amiloride
Fluoxetine
MIS416
Tcelna
Lipoic acid
Ibudilast
Anti-LINGO-1
Natalizumab
Rituximab – development terminated


Potential treatments for optic neuritis

Phenytoin
Anti-LINGO-1
Amiloride
MD1003

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